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KMID : 0369820090390040257
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Jorunal of Korean Pharmaceutical Sciences
2009 Volume.39 No. 4 p.257 ~ p.261
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A pH-specific Released Formulation Study of WHW Extract for Therapeutics of Renal Failures
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So Jae-Woo
Kang Hee-Chul
Park Yong-Ki
Kim Young-Ho
Kang Jong-Seong
Cho Cheong-Weon
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Abstract
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Effective therapeutics for renal failures have not yet been developed until now. Recently, there was a report showing that Wen-pi-tang-Hab-Wu-ling-san (WHW) prescriptions had the potential to prevent renal failures through the increased expression of HSP-27 and HSP-72 after ischemia/reperfusion. Therefore, formulation studies by pH-specific released systems were carried out to exhibit the optimal activity of WHW prescriptions in this study. WHW prescriptions were separately extracted using water into two parts of stomach-released (SR) and intestine-released (IR) extracts. Subsequently, the double-layered tablet was prepared using the SR extracts and pharmaceutical additives and enteric-coated IR tablet. Dissolution studies were carried out to figure out the release of cinnamic acid and icarrin from SR tablet, IR tablet and double-layered tablet, respectively. The complete release of cinnamic acid from SR tablet showed 90min after dissolution in pH 1.2 and insignificant drug released from IR tablet. As well as, icarrin from IR tablet completely released in pH 6.8 and 7.4 as enteric-coating film dissolved.
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KEYWORD
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Herbal medicine, WHW extract, renal failure, double-layered tablet, pH-specific
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